Dhahbi J.M. ,Tsuchiya T., Hyon-Jeen K., Mote P.L, & Spindler S.R., Gene Expression and Physiologic Responses of the heart to the Initiation and Withdrawal of Caloric Restriction. Journal of Gerontology 2006, Vol.61A, No 3, 218-231. PDF Document
Dhahbi J.M. , Mote P.L, Fahy G.M.& Spindler S.R., Identification of Potential Restriction Mimetics by Microarray Profiling. Physiol Genomics 23:343-350, November 30, 2005. First published Sept 27, 2005. PDF Document
Dhahbi J.M. & Spindler S.R. (2004) Aging of the Liver, In: Biology of Aging and its Modulation: Aging of the Organs and Systems, Vol. 3, Aspinall R. (Ed.), Kluwer Academic Publishers, Dordecht, The Netherlands, pp. 271-291.
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Dhahbi J.M., Mote P.L, Kim H.J. & Spindler S.R. (2004) Temporal Linkage Between the Phenotypic and Genomic Responses to Caloric Restriction. Proc. Natl. Acad. Sci. U.S.A. Apr 13;101(15):5524-9. Epub 2004 Mar 25. PDF format
Tsuchiya T., Dhahbi J.M., Cui X., Mote P.L, Bartke A. & Spindler S.R. (2004) Additive Regulation of Hepatic Gene Expression by Dwarfism and Caloric Restriction. Physiol. Genomics, Mar 2004; 10.1152/physiolgenomics.00039.2004. PDF format
Spindler S.R. (2003) Caloric Restriction, Longevity and the Search for Authentic Anti-Aging Drugs, In: Anti-Aging Therapy for Plastic Surgery, Kinney B. & Carraway J. (Eds.), Quality Medical Publishing, Inc., St. Louis. In Press. PDF format
Spindler S.R., Dhahbi J.M., Mote P.L., Kim H.J. & Tsuchiya T. (2003) Rapid Identification of Candidate CR Mimetics Using Microarrays. Presented at The International Association of Biomedical Gerontology, 10th Congress, Strategies for Engineered Negligible Senescence: Reasons Why Genuine Control of Aging may be Foreseeable, Queens’ College, Cambridge, England, 19-23 September 2003. PDF format
Spindler S.R., Dhahbi J.M. & Mote, P.L. (2003) Protein Turnover, Energy Metabolism, Aging, and Caloric Restriction, In: Energy Metabolism and Lifespan Determination: Advances in Cell Aging and Gerontology, Vol. 14, Mattson M.P. (Ed.), Elsevier, Amsterdam, The Netherlands, pp. 69-86.
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Cao S.X., Dhahbi J.M., Mote P.L. & Spindler, S.R. (2001) Genomic Profiling of Short- and Long-Term Calorie Restriction in the Liver of Aging Mice. Proc. Natl. Acad. Sci. U.S.A. 98:10630-10635. PDF format |
Other BioMarker publications, provided upon request:
Dhahbi J.M., Mote P.L., Cao S.X. & Spindler S.R. (2003) Hepatic gene expression profiling of streptozotocin-induced diabetes. Diabetes Tech. Therapeut. 5:411-420.
Dhahbi J.M., Cao S.X., Mote P.L., Rowley B.C., Wingo J.E. & Spindler S.R. (2002) Postprandial induction of chaperone gene expression is rapid in mice. J. Nutr. 132:31-37.
Dhahbi J.M., Cao S.X., Tillman J.B., Mote P.L., Madore M., Walford R.L & Spindler S.R. (2001) Chaperone-mediated regulation of hepatic protein secretion by caloric restriction. Biochem. Biophys. Res. Commun. 284:335-339.
Dhahbi J.M., Mote P.L., Wingo J., Tillman J.B., Walford R.L. & Spindler S.R. (1999) Calories and aging alter gene expression for gluconeogenic, glycolytic, and nitrogen-metabolizing enzymes. Am. J. Physiol. 277:352-360.
Dhahbi J.M., Mote P.L., Wingo J., Rowley B.C., Cao S.X., Walford R.L. & Spindler S.R. (2001) Caloric restriction alters the feeding response of key metabolic enzyme genes. Mech. Ageing Devel. 122:1033-1048.
Dhahbi J.M., Tillman J.B., Cao S., Mote P.L., Walford R.L. & Spindler S.R. (1998) Caloric intake alters the efficiency of catalase mRNA translation in the liver of old female mice. J. Gerontol. A Biol. Sci. Med. Sci. 53:B180-185.
Dhahbi J.M., Mote P.L., Tillman J.B., Walford R.L. & Spindler S.R. (1997) Dietary energy tissue-specifically regulates endoplasmic reticulum chaperone gene expression in the liver of mice. J. Nutr. 127:1758-1764.
Tillman J.B., Dhahbi J.M., Mote P.L., Walford R.L. & Spindler S.R. (1996) Dietary calorie restriction in mice induces carbamyl phosphate synthetase I gene transcription tissue specifically. J. Biol. Chem. 271:3500-3506.
Tillman J.B., Mote P.L., Dhahbi J.M., Walford R.L. & Spindler S.R. (1996) Dietary energy restriction in mice negatively regulates hepatic glucose-regulated protein 78 (GRP78) expression at the posttranscriptional level. J. Nutr. 126:416-423. |
